The first that comes to mind is the new health law that is still in the process of being developed and digested by many businesses.
I owned a startup manufacturing business and I would say that complying with as many regulations as possible made it very difficult to succeed. Everywhere I turned there was a government hand waiting for their due.
We can say that everybody's viewpoint is some political talking point and they all to some degree have validity.
A regulation that is yet to hit is the CalOSHA ergonomic standard that will have a significant impact on all businesses. Where does it stop?